, Fan ST, Barry C, Higgins J, Lai KM, Ji J, Dudoit

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Massimino et al. Molecular Cancer 2012, 11:21 http://www.molecular-cancer.com/11/1/SHORT COMMUNICATIONOpen AccessIRF5 promotes the proliferation of human thyroid cancer cellsMichele Massimino1, Paolo Vigneri1, Manuela Fallica1, Annamaria Fidilio1, Alessandra Aloisi1^, Francesco Frasca1 and Livia Manzella1*AbstractBackground: Interferon Regulatory Factor 5 is really a transcription element that regulates the expression of genes involved inside the response to viral infection and in the stimulation of the immune system. In addition, a number of studies have demonstrated that it negatively regulates cell growth and oncogenesis, favoring cell differentiation and apoptosis. Thyroid carcinoma represents 98 of all thyroid malignancies and has shown a steady raise in incidence in each the USA and western European countries. Findings: We investigated the expression, localization and function of IRF5 in thyroid cancer cells and discovered that it's hugely expressed in each key and immortalized thyroid carcinomas but not in standard thyrocytes. IRF5 levels have been variably modulated by Interferon alpha but IRF5 only localized within the cytoplasmic compartment, hence failing to Ch function to restore CNS homeostasis by clearing broken cells and induce p21 expression as previously reported in distinctive cell models. Furthermore, ectopic IRF5 improved each PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28549975 the proliferation price along with the clonogenic prospective of malignant thyroid cells, defending them from the cytotoxic effects of DNA-damaging agents. These final results were directly attributable to IRF5, as demonstrated by the reduction in colony-forming potential of thyroid cancer cells immediately after IRF5 silencing. An IRF5-dependent induction of endogenous B-Raf observed in all thyroid cancer cells might contribute to these unexpected effects. Conclusions: These findings recommend that, in thyroid malignancies, IRF5 displays tumor-promoting as an alternative to tumor-suppressor activities. Keyword phrases: IRF5, Thyroid Cancer, Cell ProliferationBackground Interferon Regulatory Factor five plays critical roles within the regulation of genes induced by viral infection, cell development, oncogenesis and apoptosis [1-8]. IRF5 was identified as a regulator of type I Interferon [9] and further research revealed that IRF5 displays some tumor-suppressor properties as it can induce p21, Bak, Bax, and Caspase 8 [10-12]. Thyroid carcinoma represents a unique model to study human carcinogenesis since it comprises tumors with distinctive clinical and histological features [13]., Fan ST, Barry C, Higgins J, Lai KM, Ji J, Dudoit S, Ng IOL: Gene Expression Patterns in Human Liver Cancers. Mol Biol Cell 2002, 13(six):1929. 35. Llovet JM, Chen Y, Wurmbach E, Roayaie S, Fiel MI, Schwartz M, Thung SN, Khitrov G, Zhang W, Villanueva A, et al: A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology 2006, 131(6):1758-1767.doi:ten.1186/1476-4598-11-14 Cite this short article as: Poh et al.: Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth issue receptor-4 signaling in hepatocellular carcinoma. Molecular Cancer 2012 11:14.Submit your next manuscript to BioMed Central and take full advantage of:?Handy on the net submission ?Thorough peer overview ?No space constraints or color figure charges ?Immediate publication PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28380356 on acceptance ?Inclusion in PubMed, CAS, Scopus and Google Scholar ?Study which can be freely obtainable for redistributionSubmit your manuscript at www.biomedcentral.com/submit