, imatinib has shown promising final results as a therapeutic agent in metastatic

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, imatinib has shown promising outcomes as a therapeutic agent in metastatic melanoma individuals with c-KIT mutations [30].Conclusion and future directions Pegylated interferon alpha-2b, Firategrast price vemurafenib and ipilimumab have been approved for treatment of melanoma by Meals and Drug Administration in the past year. N Engl J Med 2011, 364(26):2507-16. 4. Hodi FS, et al: Enhanced survival with ipilimumab in sufferers with metastatic melanoma. N Engl J Med 2010, 363(eight):711-23. five. Jemal A, et al: Cancer statistics, 2010. CA Cancer J Clin 2010, 60(5):277-300. six. Howlader N, et al: Enhanced estimates of cancer-specific survival prices from population-based information. J Natl Cancer Inst 2010, 102(20):1584-98. 7. Bestak R, Halliday GM: Chronic low-dose UVA irradiation induces nearby suppression of get in touch with hypersensitivity, Langerhans cell depletion and suppressor cell activation in C3H/HeJ mice. Photochem Photobiol 1996, 64(six):969-74. eight. Haluska FG, Hodi FS: Molecular genetics of familial cutaneous melanoma. J Clin Oncol 1998, 16(2):670-82. 9. Kraemer KH, et al: The function of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm. Arch Dermatol 1994, 130(eight):1018-21. 10. Karakousis CP, et al: Regional recurrence in malignant melanoma: long-term final results in the multiinstitutional randomized surgical trial., imatinib has shown promising outcomes as a therapeutic agent in metastatic melanoma individuals with c-KIT mutations [30].Conclusion and future directions Pegylated interferon alpha-2b, vemurafenib and ipilimumab have been approved for therapy of melanoma by Food and Drug Administration in the previous year. Novel agents, like tyrosine kinase inhibitors and adoptive cellular therapy, are being explored. It truly is foreseeable that agents with novel mechanisms of action are going to be studied for this difficult malignancy [39-41].Abbreviations BRAF: serine/threonine protein kinase; SLNB: sentinel lymph node biopsy; IFN: Interferon alfa; ECOG: eastern cooperative oncology group; DFS: disease PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28461567 free of charge survival; OS: general survival; FDA: food and drug administration; HDI: high dose interferon; MU: million units; LDI: low dose interferon; Obs: observations; RFS: relapse totally free survival; EORTC: European organization for analysis and therapy of cancer; PEG-IFN: pegylated interferon; DTIC: dacarbazine: IL-2: interleukin two; CTLA: cytotoxic T lymphocyte antigen; HLA: human leukocyte antigen; ATCT: adoptive T cell therapy; TIL: tumorLee et al. Journal of Hematology Oncology 2012, five:three http://www.jhoonline.org/content/5/1/Page 7 ofinfiltrating lymphocytes; TCR: T cell receptors; MART: melanoma linked antigen recognized by T cells; MAP: mitogen activated protein; ERK: extracellular signal regulated kinase; GIST: gastrointestinal stromal tumor; TKI: tyrosine kinase inhibitor; PDGF: platelet derived development factor. Acknowledgements This study was supported in element by NYMC PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27689333 Blood Disease Fund (DL). Authors' contributions All authors participated in notion design and style, data collection and evaluation, drafting and critically revising the manuscript. All authors read and authorized the final manuscript. Competing interests The authors declare that they have no competing interests. Received: ten January 2012 Accepted: 14 February 2012 Published: 14 February 2012 References 1. DeVita VT, Lawrence TS, Rosenberg SA: DeVita, Hellman, and Rosenberg's cancer: principles practice of oncology.