Population with Han ancestry in northern China.Material and methodsSubjectsstudy. The

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The control group was composed of subjects who did not have cerebrovascular Geldanamycin manufacturer diseases themselves, and no family history of cerebrovascular diseases for a minimum of three generations. Single markers in association with the disease were assessed using 2 tests in Haploview Version 4.2 (Broad Institute, Cambridge, MA, USA). Odds ratios (ORs) and 95 confidence intervals (CIs) were calculated using logistic regression analysis. Statistical analysis was performed using by SPSS version 15.0 statistical software (SPSS, Inc., Chicago, IL, USA). A value of P PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25957400 were excluded from this study. The control group was composed of subjects who did not have cerebrovascular diseases themselves, and no family history of cerebrovascular diseases for a minimum of three generations. All the subjects in this study were from different families of Han ethnicity whose families have lived in the Northeastern part of China, including Heilongjiang, Jilin and Liaoning, for more than 3 generations. This study was approved by the Institutional Review Board of the Fourth Affiliated Clinical Hospital of Harbin Medical University and each participant provided written informed consent.DNA extraction and genotypingData are presented as mean ?standard deviation or number (percentage).